Evaluation of endometrial urocortin secretion for prediction of pregnancy after intrauterine insemination.

نویسندگان

  • Pasquale Florio
  • Luca Bruni
  • Carmen De Falco
  • Gilda Filardi
  • Michela Torricelli
  • Fernando M Reis
  • Letizia Galleri
  • Chiara Voltolini
  • Caterina Bocchi
  • Vincenzo De Leo
  • Felice Petraglia
چکیده

BACKGROUND Urocortin is a neuropeptide produced by the human endometrium and has biological effects putatively important for promoting blastocyst implantation. We measured urocortin concentrations in samples of endometrial wash fluid collected from women with unexplained infertility who underwent intrauterine insemination (IUI). METHODS Patients 28-42 years of age (n = 71) were consecutively enrolled after a complete clinical evaluation. Endometrial wash fluid was retrieved before IUI, at the time of ultrasound evaluation of endometrial thickness. Urocortin concentrations were assayed with a specific ELISA. RESULTS After IUI, 28 patients (39%) became pregnant. Urocortin concentrations were significantly higher in women who became pregnant than in those who did not (0.38 microg/L vs 0.13 microg/L, P <0.0001). At a cutoff of 0.321 microg/L, urocortin results were positive in 61% [95% confidence interval (CI), 41%-78%] of women who had successful implantation and negative in 98% (95% CI, 88%-99.6%) of those who did not. The pregnancy rate for women with urocortin concentrations >0.32 microg/L was 94%, which differed significantly (P <0.05) from the overall pregnancy rate of 39% in the study population. CONCLUSIONS Urocortin is measurable in endometrial wash fluid, and its concentrations before IUI are higher in women who subsequently achieve pregnancy. These data suggest that the probability of having a successful pregnancy-producing IUI may be better estimated by measuring urocortin in endometrial wash fluid.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-148: Predictive Factors for Pregnancy after Intrauterine Insemination: A Retrospective Study of Factors Affecting Outcome

Background: Controlled ovarian hyper stimulation (COH) in conjunction with intrauterine insemination (IUI) is frequently used to treat various causes of infertility in couples. In this study we evaluate the relation between IUI outcomes and infertility with the intent to detect the most important parameters that pertain to a successful IUI. Materials and Methods: In this cross-sectional study, ...

متن کامل

Do Endometrial Movements Affect The Achievement of Pregnancy during Intrauterine Insemination?

BACKGROUND This study was aimed to assess the effect of endometrial movements on pregnancy achievement in intrauterine insemination (IUI) cycles. MATERIALS AND METHODS The population of this observational study was composed of unexplained infertility couples undergoing first-time IUI with clomiphene citrate between September 2010 and October 2011. Not only endometrial movements, but also thic...

متن کامل

Evaluating The Effective Factors in Pregnancy after Intrauterine Insemination: A Retrospective Study

Background Controlled ovarian hyperstimulation (COH) in conjunction with intrauterine inseminations (IUI) are commonly used to treat infertile couples. In this study we evaluated the relationship between IUI outcome and special causes of infertility. We also aimed to examine parameters that might predict success following IUI. MaterialsAndMethods In this cross-sectional study, we included 994 I...

متن کامل

THE EFFECT OF ENDOMETRIAL PATTERN AND THICKNESS ON PREGNANCY RATE IN CONTROLLED OVARIAN HYPERSTIMULATION-INTRAUTERINE INSEMINATION

Objective: In order to evaluate the endometrium by ultrasound in patients undergoing controlled ovarian hyperstimulation (COH) with clomiphene citrate (CC) and human menopausal gonadotropin (HMG) with intrauterine insemination (IUI) to determine the relationship between endometrial pattern and thickness on pregnancy rate (PR). Methods: In this prospective study, 108 infertile couples under...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical chemistry

دوره 54 2  شماره 

صفحات  -

تاریخ انتشار 2008